NGF: THE MOLECULE THAT REGENERATES THE BRAIN
In recent years, research into neurogenesis—the brain's ability to create new neurons—has been booming. At the heart of this process, one molecule has particularly caught the attention of scientists: Nerve Growth Factor , or NGF . Discovered in 1952, this nerve growth factor has become a pillar of cognitive health.
A key protein of the nervous system
NGF is a neurotrophin , a protein specialized in supporting neuronal life. It acts as a biochemical messenger, orchestrating the growth, differentiation, protection, and repair of neurons . Its preferred target? Cholinergic neurons , directly involved in memory and executive functions.
But its action does not stop there: NGF is also a modulator of inflammation , an actor in the immune system , and a potential regulator of pain perception .
Plasticity, resilience and cognition
NGF plays a central role in brain plasticity , the brain's fascinating ability to adapt, learn, or recover from trauma. By promoting the growth of neuronal extensions (neurites), it helps improve synaptic connections , and therefore communication between neurons.
Maintaining a good level of NGF is now considered a lever for preventing cognitive aging , and a factor of resilience in the face of oxidative stress and neurodegenerative disorders .
NGF and neurogenesis: what does science say?
Research has shown that optimal levels of NGF:
• Promotes memory and learning
• Improve concentration
• Support the creation of new neurons (neurogenesis)
• Protect the brain against injury, chronic stress and certain neurodegenerative diseases
It is even being studied in connection with pathologies such as Alzheimer's disease, depression or post-traumatic brain injuries.
What if nature had a solution?
Among the natural avenues for stimulating NGF, one candidate stands out: Hericium erinaceus , or lion's mane. This medicinal mushroom contains unique compounds, hericinones and erinacines , capable of activating NGF production in the brain , according to several in vitro and in vivo studies.
This property makes it a promising ally for neuronal health , particularly in the areas of memory, mental clarity and nerve regeneration .
NGF now represents a new avenue of exploration for understanding and supporting brain health. Its ability to nourish, repair, and protect neurons makes it a real lever for maintaining cognitive balance , particularly in the context of stress, mental overload, or aging. A discreet, but essential molecule for those who wish to maintain their brain capital on a daily basis.
